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Cardiogen

Cardiogen is the tetrapeptide Ala-Glu-Asp-Arg (AEDR), molecular weight approximately 489 Da, originally derived from research on bovine cardiac tissue extracts. It is the cardiac-specific member of the Khavinson bioregulator series, proposed to modulate gene expression in cardiomyocytes, the contractile cells of the heart.

At roughly 489 Da, Cardiogen is the heaviest of the AED-family tetrapeptides, its arginine fourth residue setting it apart from Epitalon (AEDG), Bronchogen (AEDL), and Cortagen (AEDP), which share its first three residues. Arginine is basic and positively charged at physiological pH, giving Cardiogen a different charge profile from its neutral-tailed relatives. It is the only compound in the series oriented toward myocardial tissue. Preclinical reports from the originating group describe work in experimental cardiac ischemia models, cardiomyocyte proliferative activity, and electrophysiological endpoints. As with the rest of the class, that evidence is preclinical and concentrated in a single research group, and no controlled independent replication has been published.

Supplied as a lyophilized 10-vial 20mg kit for in vitro research use only.