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KPV
KPV is the C-terminal tripeptide fragment (Lys-Pro-Val) of alpha-melanocyte-stimulating hormone (alpha-MSH). Unlike full-length melanocortin peptides, KPV is studied for anti-inflammatory signaling without pigmentary activity, which makes it a distinct tool in inflammation research.
In vitro work focuses on NF-kappaB pathway modulation, pro-inflammatory cytokine signaling, and gut and mucosal barrier integrity, with recurring interest in intestinal and epithelial inflammation models. It also appears as the anti-inflammatory component that distinguishes the Klow blend from Glow. Its compact tripeptide structure and melanocortin lineage are the features most examined in characterization studies. Supplied as a lyophilized 10-vial 10mg kit for in vitro research use only.