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Pancreagen

Pancreagen is the tetrapeptide Lys-Glu-Asp-Trp (KEDW), the pancreatic member of the Khavinson bioregulator series, proposed to modulate gene expression in pancreatic tissue.

Its research profile is more molecularly specific than most of the series. Cell-based studies have examined Pancreagen's proposed influence on pancreatic gene-expression programs, including transcription factors associated with beta-cell identity and insulin signaling, and molecular docking analyses have been used to model how the peptide might interact with DNA regulatory regions. Structurally, KEDW is the KED core plus tryptophan, making it a single-residue variant of Prostamax (KEDP) and a close relative of Livagen (KEDA), Vesugen (KED), and Testagen (KED). That one-residue separation between peptides described for entirely different organs is a recurring point of discussion around the organ-specificity hypothesis.

Supplied as a lyophilized 10-vial 20mg kit for in vitro research use only.