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Retatrutide
Retatrutide is a triple receptor co-agonist acting at the GIP, GLP-1, and glucagon receptors, and one of the most-studied investigational peptides in current metabolic research. The addition of glucagon-receptor activity is the defining distinction from the dual agonist tirzepatide and single-receptor semaglutide.
In vitro and preclinical work focuses on multi-receptor pharmacodynamics, insulin and glucagon signaling balance, energy expenditure pathways, and lipid metabolism, with particular attention to how glucagon-receptor engagement contributes to the overall metabolic profile. Because it is investigational, retatrutide is studied strictly in research contexts rather than approved use. Supplied as a lyophilized 10-vial kit across 10mg to 60mg sizes for in vitro research use only.