Eloralintide 10mg research peptide vial — Next-Generation Amylin Analogue

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Amylin

Eloralintide

Next-Generation Amylin Analogue

Eloralintide (development code LY3841136) is a selective amylin receptor agonist, supplied here as unformulated lyophilized peptide for laboratory research. It is a 37-residue amylin analogue carrying a fatty-diacid chain that drives reversible albumin binding, the structural feature behind its extended research half-life.

What distinguishes eloralintide within the amylin class is receptor selectivity. In published human receptor assays it activates the AMY1 receptor considerably more potently than the calcitonin receptor or the AMY3 receptor, a narrower profile than broad amylin analogues such as cagrilintide. In vitro research focuses on amylin receptor binding and activation kinetics, receptor-subtype selectivity, and appetite and metabolic-homeostasis signaling, often benchmarked against the GLP-1 and GIP incretin pathways.

Eloralintide is investigational and has not been approved by any regulatory authority. Supplied as a lyophilized 10-vial kit at 10 mg per vial (100 mg total peptide), tested to ≥99% purity by HPLC with molecular identity confirmed by mass spectrometry. For in vitro research use only.

$580
1
$580
per 10-vial kit
$5.80 / mg
Research Library
Eloralintide Research Review →
Mechanism, evidence level & in vitro context
Comparison Guide
Eloralintide vs Cagrilintide →
Selective AMY1R vs broad amylin/calcitonin activity
CategoryGLPs & Metabolics
Alt. nameLY3841136
ClassSelective amylin (AMY1R) agonist
Purity◆ ≥99%
FormLyophilized powder
Kit size10 vials
Per vial10mg
Storage−20°C recommended
UseResearch only
Certificate of Analysis
Available upon request. Custom and large batch orders include a batch-specific COA.
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⚠ For in vitro research use only. Not for human or animal consumption. Not evaluated by the FDA. Read full disclaimer →
Common Questions
What is Eloralintide?+
Eloralintide is a Next-Generation Amylin Analogue supplied for laboratory research. Next-generation selective amylin (AMY1) receptor agonist, advanced into Phase 3 clinical development through the ENLIGHTEN program, studied for central receptor binding dynamics, appetite-pathway signaling analysis, and metabolic homeostasis modeling.
What makes Eloralintide a next-generation amylin analogue?+
Eloralintide is a selective amylin receptor agonist, designed for more targeted amylin-pathway activation than earlier, broader analogues such as cagrilintide. In published human receptor assays it favours the AMY1 receptor over the calcitonin and AMY3 receptors. It is studied for appetite and metabolic-homeostasis signaling, and remains investigational.
How is Eloralintide different from Cagrilintide?+
Both are long-acting amylin analogues, but they differ in receptor coverage. Eloralintide (LY3841136) is selective for the AMY1 receptor, activating it far more potently than the calcitonin or AMY3 receptors. Cagrilintide (AM833) is a broad amylin analogue that also engages the calcitonin receptor. Cagrilintide also has the longer research record, largely through the semaglutide combination studied as CagriSema. The two have never been compared head-to-head in humans.
What is lyophilized Eloralintide, and how is it reconstituted?+
Eloralintide is supplied as a lyophilized (freeze-dried) powder, a dehydrated form that keeps the peptide stable during shipping and storage. In the laboratory it is reconstituted (returned to liquid form) using a solvent such as bacteriostatic water, added slowly against the side of the vial, which is then swirled gently, never shaken, until the powder fully dissolves. All handling is for in vitro research use only.
How should Eloralintide be stored?+
Store the lyophilized Eloralintide powder at -20°C, protected from light and moisture, where it remains stable long-term. Once reconstituted, keep it refrigerated (2-8°C) and use it within the timeframe appropriate for your research protocol.
What is the purity of Eloralintide, and how is it tested?+
Every batch of Eloralintide is produced to a purity of 99% or higher. Purity and molecular identity are verified using standard analytical methods: high-performance liquid chromatography (HPLC) to measure purity, and mass spectrometry (MS) to confirm the peptide's molecular weight.