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Mots-c
MOTS-c is a mitochondrial-derived peptide (MDP) encoded within the mitochondrial 12S rRNA region, a member of a small class of peptides expressed from the mitochondrial genome rather than nuclear DNA. That origin is what makes it distinct in metabolic research.
In vitro and preclinical studies examine AMPK activation, glucose uptake and insulin-signaling pathways, metabolic-stress and exercise-mimetic responses, and nuclear translocation under metabolic stress. It is frequently grouped with SS-31 and NAD+ in mitochondrial and cellular-energy research, though its mechanism as a genome-encoded signaling peptide is unique. Supplied as a lyophilized 10-vial kit across 10mg to 40mg sizes for in vitro research use only.