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Thymogen

Thymogen is the dipeptide Glu-Trp (EW), synthesized in the 1970s by Vladimir Khavinson and Vyacheslav Morozov and originally identified as the active dipeptide fragment of thymalin, a complex thymic tissue extract.

Thymogen is the outlier of this catalogue in one important respect. Where nearly every other peptide bioregulator remains almost entirely preclinical, Thymogen is the most clinically developed member of the class: it has been registered and used in Russia since the early 1990s as an immunomodulator in injectable, intranasal, and topical formulations. Structurally it is also atypical, being one of only two dipeptides in the series alongside Vilon (Lys-Glu), and the only one built on tryptophan. Research focuses on T-lymphocyte differentiation and maturation and on T-cell subset ratios. It sits alongside Vilon and TA-1 in the thymic and immune peptide group, distinguished from the 28-residue TA-1 by its minimal two-residue structure.

Supplied as a lyophilized 10-vial 20mg kit for in vitro research use only.